Diastereoselective desymmetrisation of cyclic meso-anhydrides and derivatisation for use in natural product synthesis
This thesis describes the development of a new method to desymmetrise <i>meso</i>-succinic and glutaric anhydrides and its application in the synthesis of a fragment of the biologically active natural product rapamycin. It is divided into four chapters: - Chapter one provides an introduc...
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University of Cambridge
2007
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598878 |