The destabilising effects of tumorigenic p53 mutations
The tumour suppressor p53 is mutated in half of all human cancers, most frequently with missense substitutions in its core domain. The two most frequent mutations remove DNA-binding interactions, but the majority of mutations destabilise the core domain structure. I have established an assay for the...
| Main Author: | |
|---|---|
| Published: |
University of Cambridge
2000
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597077 |