Hepatic clearance of tissue plasminogen activator (t-PA) : the role of PAI-1
The clearance of t-PA and the role of protease inhibitors in this process was examined by comparing the rate of t-PA and pre-formed t-PA-PAI-1 complex in an isolated rat liver perfusion system. Pharmacokinetic analysis of the effluent concentration vs. time curves revealed that t-PA-PAI-1 complex is...
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University of Aberdeen
1991
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.593834 |