Disrupting the inhibitory Kappa B kinase (IKK)-Aurora A axis in cancer
The IKK complex is an essential regulator of the NF-κB- signalling pathway. It is comprised of three sub-units; catalytic subunits IKKα and IKKβ and the catalytically inactive scaffolding protein IKKγ/NF-κB Essential Modulator (NEMO). The complex can be assembled in multiple conformations as either...
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University of Strathclyde
2013
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588968 |