Development of a synthetic uPAR targeted gene delivery system

Preliminary flow cytometry experiments studied the ability of the peptides, CLNGGTC (u7) and GVSNKYFSNIHWG (Gu11G), derived from the binding region of uPA to inhibit uPA-FITC binding to U937 cells. The optimised trimethylated chitosan oligomer (TMO) was functionalised with chloroacetic acid to give...

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Bibliographic Details
Main Author: Kean, Thomas
Published: Cardiff University 2006
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.583842