Characterisation of an acetylation-dependent FLIP/Ku70 complex that regulates FLIP expression
c-FLlP is a major anti-apoptotic protein that prevents apoptosis mediated by death receptors. c-FLlP binds to the DISC via its tandem DEDs and the DED of FADD and inhibits the processing of procaspases 8 and 10. Overexpression of c-FLlP results in the evasion of apoptosis, a key hallmark of cancer a...
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Queen's University Belfast
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.579738 |