Mathematical modelling of drug metabolism : using in silico techniques to investigate the cytochrome P450 enzyme system in hepatic reductase null mice

In silico modelling approaches are useful since they can minimise experimental costs and once set up can be used to replace animal testing for drugs. As such modelling techniques need to be developed to reduce dependence on animals for validation of pharmacological efficacy. The work within this the...

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Bibliographic Details
Main Author: Hill, Lydia
Published: University of Dundee 2011
Subjects:
Online Access:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.578789