Synthesis of analogues of the anti-megakaryocytic agent anagrelide
The pharmaceutical agent anagrelide 1 is used to reduce the levels of circulating blood platelets in the treatment of myeloproliferative disorders by inhibiting the growth of megakaryocytes (the precursors of platelets). It is metabolised extensively in vivo into two major metabolites: 3-hydroxyanag...
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University of Newcastle Upon Tyne
2009
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.578274 |