New and established drug targets for malaria chemotherapy from lead optimisation of 2-pyridyl quinolone PfNDH2 inhibitors to semi-synthetic pyrrole Mannich base artemisinin derivatives
The rapid development of resistance to currently deployed antimalarial drugs has raised the desperate need for new chemotherapies, preferably with novel therapeutic target. This thesis explores the synthesis of novel quinolone compounds and artemisinin derivatives targeting the mitochondrial electro...
| Main Author: | |
|---|---|
| Published: |
University of Liverpool
2012
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577488 |