The development and application of magnesium amide bases in asymmetric synthesis
Using a structurally-simple and readily-available C2-symmetric magnesium bisamide, superb conversions and selectivities were achieved for the asymmetric deprotonation of a range of prochiral ketones at both -78°C (up to 95:5 er) and -20°C (up to 90:10 er). The synthesis of a selection of optically-p...
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University of Strathclyde
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.576358 |