Investigations of the metal fluoride transition state and ground state analogue complexes of HAD superfamily proteins by nuclear magnetic resonance spectroscopy
Metal fluorides (MgF3-, AIF4 - and BeF3-) have been used to mimic the transition state and ground state of phosphate transfer enzymes. The aim of this thesis is to study how phosphate transfer enzymes are able to achieve rate enhancements of 1021 over the uncatalysed reaction, using the full complem...
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University of Sheffield
2011
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574570 |