Statistical HLA type imputation from large and heterogeneous datasets

Statistical HLA type imputation from large and heterogeneous datasets

An individual's Human Leukocyte Antigen (HLA) type is an essential immunogenetic parameter, influencing susceptibility to a variety of autoimmune and infectious diseases, to certain types of cancer and the likelihood of adverse drug reactions. I present and evaluate two models for the accurate...

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Bibliographic Details
Main Author: Dilthey, Alexander Tilo
Other Authors: McVean, Gil
Published: University of Oxford 2012
Subjects:
610.0796
Genetics (life sciences) : Bioinformatics (life sciences) : Immunodiagnostics : Immunology : Mathematical genetics and bioinformatics (statistics) : Statistics (see also social sciences) : Human Leukocyte Antigen : major histocompatibility complex : imputation : prediction : autoimmune : immunology : graph : population genetics
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572468

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http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572468

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