Pd-catalysed synthesis of functionalised adenosine analogues and their characterisation as base-discriminating fluorescent probes

A novel class of 7-modified 7-deazaadenosine nucleosides has been synthesised containing diarylacetylene groups at C7. Diarylacetylene boronate esters were synthesised by chemoselective Sonogashira cross-coupling. The boronate esters were then coupled to 7-iodo-7-deazaadenine nucleosides using aqueo...

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Bibliographic Details
Main Author: De Ornellas, Sara
Other Authors: Fairlamb, Ian J. S. ; Baumann, Christoph G.
Published: University of York 2012
Subjects:
547
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572363