Proteomic and transcriptomic investigation of the mechanisms and consequences of p53 gain of function mutation in laryngeal squamous cell carcinoma
Loss of p53 function is a critical event in tumour development. It has been well documented that p53 mutation can lead to an oncogenic gain of function (GOF) associated with poorer prognosis and therapeutic response. Such mutants exert their gain-of-function properties by modifying cells through alt...
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University of Liverpool
2011
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569205 |