Characterisation of the C-type lectin receptor CLEC-2 : expression, ligands and functions

Myeloid cells express a plethora of C-type lectin receptors (CLR) that can regulate inflammatory responses. Dectin-1 belongs to a sub-family of CLRs that possesses an extracellular C-type lectin domain (CTLD) and a single YxxL intracellular motif (hemITAM) that allows signalling via Syk kinase and i...

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Bibliographic Details
Main Author: Souto Maior Mourão Sá, D.
Published: University College London (University of London) 2011
Subjects:
616
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.568240