The role of germline-encoded T cell receptor complementarity determining regions in T cell selection and function

αβ T cell Receptors (TCR) recognise peptide antigen (p) presented on Major Histocompatability Complexes (MHC) via Complementarity Determining Regions (CDRs). TCRs are required to respond to a vast plethora of differing antigens and the CDR regions are suitably diverse, encoded by an array of gene-se...

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Bibliographic Details
Main Author: Holland, Stephen
Other Authors: Dyson, Julian ; George, Andrew
Published: Imperial College London 2013
Subjects:
610
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.568026