Investigation of transcriptional targeting and DNA lesion resolution of Activation Induced Deaminase by cofactor analysis
Activation Induced Deaminase (AID) is a crucial protein in B cells, required for a functional humoral immune system. The regulation and the molecular mechanism of AID is the focus of my thesis. As an enzyme, AID induces mutations and recombination in immunoglobulin genes, leading to increased antibo...
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University College London (University of London)
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.565689 |