Cdc7/ASK kinase as a novel target for anti-cancer drug development programmes
Targeting Cdc7, a kinase essential for DNA replication initiation, results in potent cancer cell killing. Cancer cells in which CDC7 is silenced by RNAi enter an abortive S phase followed by apoptosis due to loss of a functioning DNA replication origin activation checkpoint. This checkpoint prevents...
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University College London (University of London)
2011
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.565425 |