The role of Zap70 in thymocyte development
CD4+CD8+ double positive (DP) precursors undergo positive selection in the thymus, and subsequently commit to either the CD4 or CD8 single positive (SP) lineage. Mice lacking Zap70, a crucial kinase involved in T-cell receptor (TCR) signal transduction are developmentally arrested at the DP stage, s...
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University College London (University of London)
2010
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564791 |