The expansion of mutant clones in tumorigenesis
The formation of a cancer is an evolutionary process. A somatic cell may acquire an (epi)-mutation that gives it a growth advantage relative to its neighbours. Progression to cancer occurs as cells in the resulting mutant clone acquire additional mutations, which may also confer a selective advantag...
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University College London (University of London)
2009
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564725 |