Modelling altered glucocorticoid sensitivity : from HPA axis to metabolic abnormalities in mice and humans
The primary determinants of tissue glucocorticoid action are glucocorticoid receptor (GR) density and intracellular levels of ligand, the latter determined both by activity of the hypothalamic-pituitary-adrenal (HPA) axis and cellular activity of 11beta- hydroxysteroid dehydrogenase (11beta-HSD) enz...
| Main Author: | |
|---|---|
| Other Authors: | |
| Published: |
University of Edinburgh
2008
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.562206 |