Investigating the protein and RNA interactions of the Polypyrimidine Tract Binding protein : high resolution structures with implications in the regulation of alternative splicing
Alternative splicing produces multiple mRNAs from a single gene. It is a powerful mechanism used to amplify complexity of the metazoan proteome. The Polypyrimidine Tract Binding protein (PTB) is a key regulator of alternative splicing. In addition, it has roles in the localization and stability of m...
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Imperial College London
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.556550 |