The influence of copper (II) ions on the structure and stability of the prion protein and its interaction with the amyloid-beta peptides

The prion protein (PrPC) is a cell surface glycoprotein that binds Cu2+ ions. The misfolding and oligomerisation of PrPC is responsible for a range of transmissible spongiform encephalopathies (TSEs) in mammals. As changes in PrPC conformation are intimately linked with disease pathogenesis, the eff...

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Bibliographic Details
Main Author: Younan, Nadine D.
Published: Queen Mary, University of London 2012
Subjects:
Online Access:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.552731

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