The influence of copper (II) ions on the structure and stability of the prion protein and its interaction with the amyloid-beta peptides
The prion protein (PrPC) is a cell surface glycoprotein that binds Cu2+ ions. The misfolding and oligomerisation of PrPC is responsible for a range of transmissible spongiform encephalopathies (TSEs) in mammals. As changes in PrPC conformation are intimately linked with disease pathogenesis, the eff...
| Main Author: | |
|---|---|
| Published: |
Queen Mary, University of London
2012
|
| Subjects: | |
| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.552731 |