Mechanisms of V600EBRAF-induced tumour development
BRAF is a serine/threonine protein kinase that functions as a component of the RAS/RAF/MEK/ERK signalling pathway. Gain-of-function BRAF mutations have been found in ~50%-70% of malignant melanomas and in a variety of other cancer types, including thyroid, colon, and lung cancers. The activating V60...
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University of Leicester
2011
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551790 |