Synthesis of sulforaphane and inhibition of cytochrome P450 enzymes as a basis for antigenotoxicity
Sulforaphane was synthesised with an overall yield of 15%, essentially via 1-methylsulfinylphthalimidobutane, which was oxidised to the sulfoxide moiety. Sulforaphane was a competitive inhibitor of CYPO2E1 in acetone-induced Sprague-Dawley rat microsomes (Ki 37.9 4.5 M), as measured by the p-nitroph...
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Aston University
1997
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544624 |