Investigation of DNA adducts formed in cells and clinical tumour biopsies following exposure to platinum-containing anticancer drugs
Platinum-based anticancer drugs are believed to exert their action through chemical reactions with genomic DNA, forming adducts with DNA bases. Although the pharmacology of such adducts has been widely studied, the cytotoxic mechanism remains unclear. The possibility that non-DNA molecules have the...
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University of Newcastle Upon Tyne
2011
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540397 |