The role of hedgehog acyltransferase & heparan sulphate proteoglycans in human sonic hedgehog signalling

Hedgehog proteins (Hh) are morphogens and major mediators in many developmental processes. Hh signalling is significant for many aspects of embryonic development, whereas dysregulation of this pathway is associated with several types of cancers. Hh proteins require dual lipidation and Heparan Sulfat...

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Bibliographic Details
Main Author: Chang, Shu-Chun
Other Authors: Magee, Tony
Published: Imperial College London 2011
Subjects:
611
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534989