The cytosolic fate of ricin A chain in target cells
Ricin is a heterodimeric, toxic plant protein. It is able to deliver its catalytic A chain (RTA) into the cytosol of target cells. RTA crosses the endoplasmic reticulum (ER) membrane into the cytosol, masquerading as a substrate of ER-associated degradation (ERAD) to do so. Therein, RTA inactivates...
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University of Warwick
2010
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.532134 |