Modulation of endoplasmic reticulum stress as a cancer therapeutic strategy using multiple myeloma as a model
The presence of correctly folded nascent immunoglobulin within the endoplasmic reticulum (ER) provides an effective checkpoint for plasma cell development. A signalling pathway called the unfolded protein response (UPR) allows cells to handle the proper folding of proteins and ensures cell survival....
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Institute of Cancer Research (University Of London)
2010
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529260 |