Enhancement of HIV-1 neutralisation by modulation of the virus envelope
Despite over 25 years of research, the goal of producing an HIV-1 vaccine able to prevent infection has not been realised. Due to the limited immunogenicity of HIV-1 glycoproteins in vivo, this thesis explores the use of cholesterol depletion in increasing the antigenicity and immunogenicity of an w...
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Imperial College London
2009
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516471 |