Investigating the chemistry of lipoyl synthase

The radical SAM protein lipoyl synthase (LipA) is essential for lipoic acid biosynthesis via sulfur insertions into the unactivated C6 and C8 centres of a protein-bound octanoyl group. Using an in vitro assay which makes use of a small peptide mimic of the protein substrate, it has now been shown at...

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Bibliographic Details
Main Author: Douglas, Paul
Other Authors: Roach, Peter
Published: University of Southampton 2008
Subjects:
540
Online Access:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501557