The role of c-fos and signal transducers and activators of transcription in the synergistic induction of MMP-1

The role of c-fos and signal transducers and activators of transcription in the synergistic induction of MMP-1

Rheumatoid Arthritis (RA) is one of the most prevalent inflammatory joint diseases in the developed world and 1% of the UK population is affected. Arthritis pathology is complex and is driven by pro-inflammatory cytokines such as Interleukin 1 (IL-1) and Tumour Necrosis Factor-a. Biologics which tar...

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Bibliographic Details
Main Author: Farren, Matthew
Published: University of Newcastle Upon Tyne 2009
Subjects:
616.722707
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500955
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spelling ndltd-bl.uk-oai-ethos.bl.uk-5009552015-03-20T05:02:54ZThe role of c-fos and signal transducers and activators of transcription in the synergistic induction of MMP-1Farren, Matthew2009Rheumatoid Arthritis (RA) is one of the most prevalent inflammatory joint diseases in the developed world and 1% of the UK population is affected. Arthritis pathology is complex and is driven by pro-inflammatory cytokines such as Interleukin 1 (IL-1) and Tumour Necrosis Factor-a. Biologics which target these cytokines have proved successful in the clinic although not all patients respond to these treatments suggesting that other pro-inflammatory cytokines are involved. Research has suggested a role for Oncostatin M (OSM) in the pathology of arthritis and studies have suggested OSM can synergise with IL-1 to promote cartilage catabolism.616.722707University of Newcastle Upon Tynehttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500955Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 616.722707
spellingShingle 616.722707
Farren, Matthew
The role of c-fos and signal transducers and activators of transcription in the synergistic induction of MMP-1
description Rheumatoid Arthritis (RA) is one of the most prevalent inflammatory joint diseases in the developed world and 1% of the UK population is affected. Arthritis pathology is complex and is driven by pro-inflammatory cytokines such as Interleukin 1 (IL-1) and Tumour Necrosis Factor-a. Biologics which target these cytokines have proved successful in the clinic although not all patients respond to these treatments suggesting that other pro-inflammatory cytokines are involved. Research has suggested a role for Oncostatin M (OSM) in the pathology of arthritis and studies have suggested OSM can synergise with IL-1 to promote cartilage catabolism.
author Farren, Matthew
author_facet Farren, Matthew
author_sort Farren, Matthew
title The role of c-fos and signal transducers and activators of transcription in the synergistic induction of MMP-1
title_short The role of c-fos and signal transducers and activators of transcription in the synergistic induction of MMP-1
title_full The role of c-fos and signal transducers and activators of transcription in the synergistic induction of MMP-1
title_fullStr The role of c-fos and signal transducers and activators of transcription in the synergistic induction of MMP-1
title_full_unstemmed The role of c-fos and signal transducers and activators of transcription in the synergistic induction of MMP-1
title_sort role of c-fos and signal transducers and activators of transcription in the synergistic induction of mmp-1
publisher University of Newcastle Upon Tyne
publishDate 2009
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500955
work_keys_str_mv AT farrenmatthew theroleofcfosandsignaltransducersandactivatorsoftranscriptioninthesynergisticinductionofmmp1
AT farrenmatthew roleofcfosandsignaltransducersandactivatorsoftranscriptioninthesynergisticinductionofmmp1
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