Analysis of genetic mutations using a recombinant model of the mammalian pyruvate dehydrogenase complex
This phenylalanine located near to the catalytic site of E2 has been found to be responsible for substrate specificity and its substitution could be directly responsible for decreased enzymatic activity in this case. No major structural changes were observed in this mutant core. In summary, our reco...
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University of Glasgow
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499428 |