Invesitagating the role of the guanine nucleotide exchange factor P-Rex1 in cell invasion

Cell invasion is a critical step in cancer metastasis. Rho family GTPases are key regulators of cell motility, regulating the form and function of the actin cytoskeleton. P-Rex1, a Rac guanine nucleotide exchange factor (GEF), was previously identified in this lab in a transcriptional screen for med...

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Bibliographic Details
Main Author: Lawn, Samuel Oliver
Published: University of Glasgow 2008
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495135