Structural modification of cinchona alkaloids for the synthesis of novel chiral fluorinating agents
The diastereoisomers 8-fluoroquininone and 8-fluoroquinidinone were synthesised, separated and their structures were determined by HOESY spectroscopy and X-ray crystallography. The addition of a methyl group to the carbonyl of 8-fluoroquinidinone led to a single diastereoisomer of 8-fluoro-9-methyl...
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University of Leicester
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492794 |