The nitric oxide/cGMP pathway regulates neutrophil adhesion through activation of rap GTPases
We found that the pro-inflammatory cytokine TNF-ex. promoted adhesion of human neutrophils to fibrinogen. However, TNF- ex. activated Rap GTPases in adherent but not suspended neutrophils. Thus, signalling through ~2 integrins is required to initiate activation of Rap GTPases. We have clearly shown...
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Queen's University Belfast
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492153 |