The molecular and cellular function of gene-modified T-cells

Chimeric Immune Receptors (CIR) consisting of a carcinoembryonic antigen (CEA)specific single chain antibody fragment (scFv), fused to the CD3s signalling chain from the T-cell receptor (TCR), induce T-cell activation on CEA ligation. The study sought to investigate some of the structural aspects of...

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Bibliographic Details
Main Author: Bridgeman, John Stephen
Published: University of Manchester 2008
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488655