Investigating the molecular basis for p53 haploinsufficiency
A haploid genotype may be insufficient to support nonnal wild-type function. Such haplo-insufficiency has recently been documented for sevefill tumour suppressor genes. p53 is a crucial tumour suppressor orchestrating DNA repair, cell cycle arrest and apoptosis via its role as a stress-responsive tr...
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University of York
2007
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485727 |