Prostacyclin receptor signalling and cell proliferation : role in pulmonary hypertension

Prostacyclin and its stable analogues are used to treat pulmonary arterial hypertension (PAH), a disease associated with abnormal smooth muscle cell (SMC) proliferation. These analogues are thought to mediate their anti proliferative effects through prostacyclin (IP) receptors linked to cyclic AMP (...

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Bibliographic Details
Main Author: Falcetti, Emilia
Published: University College London (University of London) 2007
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445900