Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to platinum drugs in ovarian cancer

Despite improvements in tumour response and survival following platinum based therapy in ovarian cancer, both intrinsic and acquired drug resistance remain a significant problem. Mechanisms of acquired drug resistance have been studied extensively in ovarian cancer cells in culture following repeate...

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Bibliographic Details
Main Author: Shamai, Pamela Win
Published: University College London (University of London) 2006
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442061