Structural and functional analysis of the proteasome inhibitor PI31 and its interaction with the F-box protein Fbxo 7

This thesis describes the structural and functional analysis of two related proteins, PI31 and Fbxo7, both of which act within the ubiquitin-proteasome system. This system is involved in a wide variety of cellular processes. Proteins modified with ubiquitin are often targeted for degradation by the...

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Bibliographic Details
Main Author: Kirk, Rebecca Jane
Published: University College London (University of London) 2005
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425640