G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganisation of the actin cytoskeleton
G protein-coupled receptor kinase 2 (GRK2) phosphorylates and desensitises activated G protein-coupled receptors (GPCRs). In this thesis, I identify ezrin, a member of the ezrin-radixin-moesin (ERM) family of actin/plasma membrane cross- linkers, as a novel non-GPCR substrate of GRK2. GRK2 phosphory...
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University College London (University of London)
2005
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424329 |