A new route to oligonucleotides

The application of the Arbusov reaction to generate a nucleoside-containing phosphoryl halide for use in oligonucleotide synthesis has been investigated. In Arbusov reactions on mixed trialkyl phosphites, t-butyl halide is always lost in preference to methyl, ethyl or cyclo-pentyl halide. Exploitati...

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Bibliographic Details
Main Author: Weetman, John
Published: University of Leicester 1985
Subjects:
547
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356646