Structure and activity studies on mutants of the enzyme dihydrofolate reductase

During the course of this thesis four mutants of Lactobacillus casei dihydrofolate reductase have been studied to determine the role of the individual amino acids in the structure and function of the enzyme. The mutants tryptophan-21→ histidine and threonine-63 → alanine were succe...

Full description

Bibliographic Details
Main Author: Thomas, Janette Ann
Published: University of Leicester 1990
Subjects:
572
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315129