The effect of cytotoxic drugs on the DNA metabolism and proliferation of lymphoblasts

(A) The EBV transformed lymphoblastoid, Namalwa, cell line was used to investigate the effects of three cytotoxic agents on eukaryotic DNA replication. Cytosine arabinoside, an analogue of deoxycytidine, at a concentration of 5 x 10−9 M was shown to inhibit DNA synthesis by 50% in the Namalwa cell l...

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Bibliographic Details
Main Author: Fricker, Simon P.
Published: University of Warwick 1981
Subjects:
Online Access:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.255886