Characterisation of the herpes simplex virus type 1 mutant, ambUL12

The herpes simplex virus type 1 (HSV-1) UL12 gene encodes an alkaline nuclease. Although the UL12 gene is not absolutely essential for replication, UL12 null mutants produce 100-1000 fold less viable virus than wt HSV-1. It has been suggested that the alkaline nuclease functions to remove branched s...

Full description

Bibliographic Details
Main Author: Porter, Iain Malcolm
Published: University of Glasgow 2002
Subjects:
616
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248207