Molecular Evolution of Type I Collagen (COL1a1) and Its Relationship to Human Skeletal Diseases
abstract: Skeletal diseases related to reduced bone strength, like osteoporosis, vary in frequency and severity among human populations due in part to underlying genetic differentiation. With >600 disease-associated mutations (DAMs), COL1a1, which encodes the primary subunit of type I collagen, t...
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| Format: | Doctoral Thesis |
| Language: | English |
| Published: |
2010
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| Online Access: | http://hdl.handle.net/2286/R.I.8687 |