Solving the Mechanism of Na+/H+ Antiporters Using Molecular Dynamics Simulations

Solving the Mechanism of Na+/H+ Antiporters Using Molecular Dynamics Simulations

abstract: Na+/H+ antiporters are vital membrane proteins for cell homeostasis, transporting Na+ ions in exchange for H+ across the lipid bilayer. In humans, dysfunction of these transporters are implicated in hypertension, heart failure, epilepsy, and autism, making them well-established drug target...

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Bibliographic Details
Other Authors: Dotson, David Lee (Author)
Format: Doctoral Thesis
Language:English
Published: 2016
Subjects:
Biophysics
Molecular physics
Theoretical physics
antiporters
binding free energies
membrane proteins
molecular dynamics
python
research software
Online Access:http://hdl.handle.net/2286/R.I.40833

Internet

http://hdl.handle.net/2286/R.I.40833

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