From Autopsy Donor to Stem Cell to Neuron (and Back Again): Cell Line Cohorts, IPSC Proof-of-Principle Studies, and Transcriptome Comparisons of In Vitro and In Vivo Neural Cells

From Autopsy Donor to Stem Cell to Neuron (and Back Again): Cell Line Cohorts, IPSC Proof-of-Principle Studies, and Transcriptome Comparisons of In Vitro and In Vivo Neural Cells

abstract: Induced pluripotent stem cells (iPSCs) are an intriguing approach for neurological disease modeling, because neural lineage-specific cell types that retain the donors' complex genetics can be established in vitro. The statistical power of these iPSC-based models, however, is dependent...

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Bibliographic Details
Other Authors: Hjelm, Brooke Erika (Author)
Format: Doctoral Thesis
Language:English
Published: 2013
Subjects:
Molecular biology
Genetics
Neurosciences
autopsy
genomics
induced pluripotent stem cells
neural differentiation
RNA-Seq
stem cell biology
Online Access:http://hdl.handle.net/2286/R.I.18696

Internet

http://hdl.handle.net/2286/R.I.18696

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